Nephroprotective Potential of Olea europaea Leaf Extract Against Combined Noise and Toluene‐Induced Oxidative and Histopathological Renal Injuries in Wistar Rats
Takoua Ben Attia, Mabrouk Horchani, Mariem Salhi, Zeineb Dhifallah, Meriem Ksentini, Hichem Ben Jannet, Abada Mhamdi
TL;DR
This study shows that Olea europaea leaf extract protects rat kidneys from damage caused by noise and toluene exposure.
Contribution
The study demonstrates the nephroprotective effects of Olea europaea leaf extract against combined noise and toluene-induced kidney injury.
Findings
OeLE reduced oxidative stress and restored renal function in rats exposed to noise and toluene.
Histopathological improvements and enhanced antioxidant activity were observed with OeLE supplementation.
Molecular docking confirmed interactions between OeLE compounds and inflammatory/oxidative mediators.
Abstract
Noise and toluene are environmental stressors that induce oxidative stress and inflammation, contributing to renal dysfunction. This study evaluated the protective effects of Olea europaea leaf extract (OeLE; 40 mg/kg/day) against combined noise‐ and toluene‐induced nephrotoxicity in Wistar rats. Forty‐eight male rats were divided into eight groups and exposed for 6 weeks (6 h/day, 5 days/week) to noise, toluene, or their combination, with or without OeLE supplementation. Renal function biomarkers (urea and creatinine), oxidative stress indices (malondialdehyde, catalase [CAT], and superoxide dismutase [SOD]), histopathology, and in silico docking targeting key redox and inflammatory mediators (CAT, SOD, IL‐1β, TNF‐α, and NF‐κB) were assessed. Co‐exposure caused significant renal dysfunction, elevated lipid peroxidation, impaired antioxidant defenses, glomerular collapse, tubular…
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Taxonomy
TopicsGenomics, phytochemicals, and oxidative stress · Air Quality and Health Impacts · Noise Effects and Management