# Olfaction and Sarcopenia in Older Adults: A Longitudinal Study

## TL;DR

This study finds that poor sense of smell in older adults is linked to a higher risk of sarcopenia, especially reduced mobility over time.

## Contribution

The study longitudinally links olfactory impairment to sarcopenia markers in older adults, showing progressive associations over time.

## Key findings

- Anosmia was strongly associated with slow gait speed and low muscle strength in older adults.
- The association between poor olfaction and sarcopenia markers increased over time.
- Only anosmia showed a significant link to low muscle strength at follow-up.

## Abstract

Olfactory impairment is associated with greater weight loss in older adults. We examined olfaction in relation to sarcopenia in 2503 participants (aged 71-82, 51.7% women, and 38.4% Black) of the Health, Aging, and Body Composition study. Olfaction was assessed in Year 3 using the 12-item Brief Smell Identification Test, categorized as good (test score: 11-12), moderate (9-10), hyposmia (7-8), and anosmia (0-6). We measured sarcopenia as slow gait speed (20-meter usual walking speed < 0.8 meters/second) or low muscle strength (grip strength < 35.5 kg for men and < 20 kg for women), which were assessed annually/biennially for up to 7 years. We conducted joint model analyses to account for covariates and potential bias due to attrition. Compared with participants with good olfaction, the multivariable adjusted odds ratio (OR) and 95% confidence interval (CI) associated with slow gait speed at baseline was 1.05(0.86, 1.29) for moderate olfaction, 1.13(0.87, 1.46) for hyposmia, and 1.98(1.50, 2.61) for anosmia. Notably, associations strengthened over time. At the end of follow-up, corresponding ORs increased to 1.80(1.17, 2.76) for moderate olfaction, 2.68(1.54, 4.67) for hyposmia and 3.74(2.09, 6.71) for anosmia. For muscle strength, we only found an association with anosmia but not hyposmia or moderate olfaction. At the end of the follow up, compared to those with good olfaction, the ORs for low muscle strength were 1.32(0.80, 2.19) for moderate olfaction, 1.19(0.63, 2.24) for hyposmia, and 3.12(1.48, 6.55) for anosmia. Poor olfaction was associated with markers of sarcopenia in older adults, particularly reduced mobility.

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Source: https://tomesphere.com/paper/PMC12760806