# Physical Activity Moderates Associations Between Sleep and Cognition in Middle-aged and Older Adults

## TL;DR

This study finds that physical activity can reduce the negative effects of poor sleep on cognitive abilities in middle-aged and older adults.

## Contribution

The study reveals that physical activity moderates the relationship between sleep quality and cognitive performance in older adults.

## Key findings

- Higher total volume of physical activity (TVPA) was linked to better attention and language performance.
- Poorer sleep efficiency and longer wake after sleep onset were associated with worse cognitive performance.
- Physical activity weakened the negative impact of poor sleep on executive function and language.

## Abstract

Higher sleep quality and greater physical activity are linked to reduced risk of cognitive decline and dementia, but little is known about the synergistic effects of sleep and physical activity on cognition in middle-aged and older adults. We examined whether physical activity moderated the association between sleep and cognition in 341 cognitively unimpaired middle-aged and older adults (mean 67.5±7.40 years, 63.6% female, 35.5% non-white, 12.9±2.3 years of education), who participated in Wave 5 of the Baltimore Epidemiologic Catchment Area Study. Sleep and physical activity measures derived from 6.8±1.6 days of wrist actigraphy included total volume of physical activity (TVPA), total sleep time (TST), sleep onset latency (SOL), sleep efficiency (SE; % time in bed spent asleep) and wake after sleep onset (WASO; minutes awake after falling asleep). Cognitive tests assessed memory, executive function, language, attention, and psychomotor speed. After adjustment for age, sex, race, and education, TVPA was positively associated with attention and language. Lower SE, greater WASO, longer SOL, and TST < 6 hours (vs. TST 6-8 hours) were associated with poorer cognitive performance. TVPA moderated the associations between SOL and executive function (interaction p < 0.05), and WASO and language (interaction p = 0.04), such that associations between lower sleep quality and poorer cognition were weaker among participants with higher TVPA. Higher TVPA was associated with better language performance among those with 6-8 or > 8 hours of TST, but not in those with TST < 6 hours. Findings suggest that greater physical activity may attenuate the negative impact of poor sleep on cognition.

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Source: https://tomesphere.com/paper/PMC12760088