# Neutrophils and Chronic Inflammation

**Authors:** Emily Goldberg

PMC · DOI: 10.1093/geroni/igaf122.819 · Innovation in Aging · 2025-12-31

## TL;DR

This paper explores how neutrophils, typically known for fighting infections, may also play a role in chronic inflammation linked to aging and diseases like diabetes and cancer.

## Contribution

The study investigates the novel role of neutrophils in sterile inflammation and age-related inflammatory conditions.

## Key findings

- Neutrophils are linked to sterile inflammatory diseases such as diabetes and cardiovascular disease.
- The research highlights a potential role for neutrophils in age-related inflammation.
- Findings suggest neutrophils may contribute to chronic inflammatory processes beyond infection.

## Abstract

Neutrophils are short-lived immune cells that are best known for their important role in antimicrobial immunity. Recently, neutrophils have been implicated in sterile inflammatory diseases like diabetes, cardiovascular disease, and cancer. We have been investigating how neutrophils might contribute to chronic inflammatory diseases, and particularly in age-related inflammation.

## Linked entities

- **Diseases:** diabetes (MONDO:0005015), cardiovascular disease (MONDO:0004995), cancer (MONDO:0004992)

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Source: https://tomesphere.com/paper/PMC12759893