Intrinsic Capacity And Longevity From Age 70-100
Jeremy Jacobs, Irit Stessman-Lande, Aliza Rozenberg, Jochanan Stessman

TL;DR
This study shows that intrinsic capacity, a measure of healthy aging, declines with age and is linked to longer survival in people aged 70 to 100.
Contribution
The study provides a detailed trajectory of intrinsic capacity decline and its association with longevity in individuals aged 70-100.
Findings
Intrinsic capacity scores consistently declined with increasing age from 70 to 100 years.
Higher intrinsic capacity was associated with improved survival, except between ages 78-85.
Males had higher intrinsic capacity scores than females at all ages studied.
Abstract
Intrinsic capacity (IC) has been proposed as a useful marker of healthy aging. This study examines the prevalence of IC between ages 70-100, and its association with survival. The Jerusalem Longitudinal Study (1990-2021) prospectively followed a community-dwelling cohort born 1920-21, at ages 70, 78, 85, 90, 95 and 100 (n = 604, 1024, 1222, 729, 508, 205 respectively). Comprehensive assessment was performed, and mortality data collected. Intrinsic capacity (0-100/minimum-maximum) was a composite of Cognition (Mini-Mental State Exam), Psychological (depression using the Basic Symptom Inventory), Vitality (BMI), Locomotion (chair transfer) and Sensory (Snellen and whisper test) domains. Kaplan-Meier survival curves, and Cox Proportional Hazard models were performed. The mean IC at ages 70, 78, 85, 90, 95, and 100 years consistently declined: 75.8, 74.0, 66.7, 64.5, 63.5, 51.8, and was…
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Taxonomy
TopicsGenetics, Aging, and Longevity in Model Organisms · Aging and Gerontology Research · Health disparities and outcomes
