# Ameliorative Effect of Beetroot Against Folic Acid Deficiency: A Review

**Authors:** Amara Rasheed, Farhan Saeed, Ali Ikram, Muhammad Tayyab Arshad, Sammra Maqsood, Feroza Naveed, Mariam Islam, Emmanuel Laryea

PMC · DOI: 10.1002/fsn3.71417 · Food Science & Nutrition · 2026-01-02

## TL;DR

This review explores how beetroot can help counteract the negative effects of folic acid deficiency due to its rich content of bioactive compounds.

## Contribution

The paper provides a holistic explanation of beetroot's medicinal properties in mitigating folic acid deficiency.

## Key findings

- Beetroot contains bioactive substances like betalain, nitrates, and folates that may counteract folic acid deficiency.
- Beetroot's antioxidative and anti-inflammatory properties make it a potential functional food for health promotion.
- Beetroot and folic acid supplements offer a nutritional intervention for folic acid insufficiency.

## Abstract

A lack of vegetables or other folate‐rich foods in the diet leads to folate insufficiency. The most significant cause of this malformation may be a lack of folic acid. Folic acid deficiency, a critical maternal health component, can result in megaloblastic anemia, neural tube anomalies, cardiovascular complications, cancer, and Deoxyribonucleic acid (DNA) imbalance. Beetroot (
Beta vulgaris
) is one of the most widely consumed vegetables worldwide. Red beets have attracted more attention because of their rich source of bioactive substances, including betalain, indolent nitrates, polyphenols, and folates, as well as minerals and vitamins found within the tuberous root. Red beets show strong potential for usage as functional ingredients in the food and healthcare industries due to their numerous health‐promoting qualities. The plant has antioxidative and anti‐inflammatory properties that may be useful in the treatment of a variety of disorders.

Beets, as well as folic acid supplements, provide a possible nutritional intervention for nutritional insufficiency, and this is especially true in functional foods. Offering a holistic explanation of beetroot's medicinal properties, this paper explores the means by which its bioactive constituents can counteract the adverse effects of folic acid deficiency.

## Linked entities

- **Chemicals:** folic acid (PubChem CID 135398658), betalain (PubChem CID 56841626), nitrates (PubChem CID 943)
- **Diseases:** megaloblastic anemia (MONDO:0001700), cancer (MONDO:0004992)
- **Species:** Beta vulgaris (taxon 161934)

## Full-text entities

- **Diseases:** neural tube anomalies (MESH:D009436), megaloblastic anemia (MESH:D000749), folate insufficiency (MESH:D000309), cardiovascular complications (MESH:D002318), Folic Acid Deficiency (MESH:D005494), cancer (MESH:D009369), inflammatory (MESH:D007249)
- **Chemicals:** nitrates (MESH:D009566), betalain (MESH:D050858), Beetroot (-), polyphenols (MESH:D059808), folate (MESH:D005492)
- **Species:** Beta vulgaris (beet, species) [taxon 161934]

## Full text

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## Figures

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## References

70 references — full list in the complete paper: https://tomesphere.com/paper/PMC12759040/full.md

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Source: https://tomesphere.com/paper/PMC12759040