# Extranodal Lymphoplasmacytic Lymphoma Responding Rapidly to Zanubrutinib: A Case Series

**Authors:** Samuel Brown, Jillian Rusbridge, George Follows, Anna Santarsieri

PMC · DOI: 10.1002/ccr3.71756 · Clinical Case Reports · 2026-01-02

## TL;DR

This paper reports three cases of rare lymphoma responding well to a drug called Zanubrutinib.

## Contribution

The study highlights the effectiveness of Zanubrutinib in treating atypical extranodal lymphoplasmacytic lymphoma.

## Key findings

- Three patients with atypical extranodal lymphoplasmacytic lymphoma showed rapid responses to Zanubrutinib.
- Zanubrutinib was associated with a limited side effect profile in these cases.
- The results suggest Zanubrutinib as a promising treatment option for this rare lymphoma subtype.

## Abstract

Management of recurrent or atypical lymphoplasmacytic lymphoma poses a significant therapeutic challenge. Here we demonstrate a case series of three patients with atypical presentations of extranodal lymphoplasmacytic lymphoma that each show remarkable and timely responses to Zanubrutinib with a limited side effect profile.

## Linked entities

- **Chemicals:** Zanubrutinib (PubChem CID 135565884)
- **Diseases:** lymphoplasmacytic lymphoma (MONDO:0000432)

## Full-text entities

- **Diseases:** Extranodal Lymphoplasmacytic Lymphoma (MESH:D008223)
- **Chemicals:** Zanubrutinib (MESH:C000629551)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12758978/full.md

## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12758978/full.md

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Source: https://tomesphere.com/paper/PMC12758978