# Effects of endocrine disruptors on the neurological system

**Authors:** Kadircan KARATOPRAK, Soner CANDER

PMC · DOI: 10.55730/1300-0144.6127 · Turkish Journal of Medical Sciences · 2025-11-11

## TL;DR

This paper reviews how endocrine disruptors in consumer products and industry may harm neurological health and contribute to diseases like Alzheimer's and autism.

## Contribution

The paper synthesizes recent epidemiological and experimental evidence linking endocrine disruptors to neurological disorders.

## Key findings

- Exposure to endocrine disruptors correlates with neurodegenerative and neurodevelopmental diseases.
- Common pollutants like bisphenol A and heavy metals significantly impact the endocrine system.
- Understanding these chemicals' roles could lead to new prevention strategies for neurological diseases.

## Abstract

There is increasing interest in endocrine disrupting chemicals because of the potential effects on neurological health. These chemicals are widely found in various consumer products and industrial processes, and can lead to serious disorders of the endocrine system by disrupting hormone synthesis, expression, and function. The aim of this review was to examine epidemiological and experimental findings by investigating the link between exposure to endocrine disrupting chemicals and adverse neurological outcomes.

In the preparation of this review, a PubMed literature search was conducted using the words “endocrine disruptors,” “neuroendocrine effects,” “neurobehavioral effects,” and “neurodevelopmental effects” and articles containing relevant studies were examined.

Recent studies have shown a strong correlation between exposure to endocrine disrupting chemicals and the development of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, and neurodevelopmental diseases such as autism spectrum disorder and attention deficit hyperactivity disorder. The effects of common pollutants such as pesticides, bisphenol A, polychlorinated biphenyls, and heavy metals on the endocrine system have been especially emphasized.

In conclusion, understanding the role played by endocrine disrupting chemicals in the development of neurological diseases will be of critical importance in the development of new strategies to prevent these diseases.

## Linked entities

- **Chemicals:** bisphenol A (PubChem CID 6623)
- **Diseases:** Alzheimer’s disease (MONDO:0004975), Parkinson’s disease (MONDO:0005180), autism spectrum disorder (MONDO:0005258), attention deficit hyperactivity disorder (MONDO:0007743)

## Full-text entities

- **Diseases:** attention deficit hyperactivity disorder (MESH:D001289), neurodevelopmental diseases (MESH:D004194), neurodegenerative diseases (MESH:D019636), Alzheimer's and Parkinson's disease (MESH:D010300), autism spectrum disorder (MESH:D000067877), neurological diseases (MESH:D020271), endocrine disruptors (MESH:D004700)
- **Chemicals:** polychlorinated biphenyls (MESH:D011078), heavy (-), bisphenol A (MESH:C006780)

## Full text

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## References

46 references — full list in the complete paper: https://tomesphere.com/paper/PMC12758925/full.md

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Source: https://tomesphere.com/paper/PMC12758925