# Different MicroRNAs expression in Mycobacterium tuberculosis and correlation with prognosis of the disease

## TL;DR

This paper reviews how different microRNAs are expressed in tuberculosis and how they may be linked to disease prognosis.

## Contribution

The paper highlights specific microRNAs associated with tuberculosis progression and drug resistance.

## Key findings

- miRNA-146 is more highly expressed in TB patients' serum exosomes compared to healthy individuals.
- Drug-resistant tuberculosis is linked to miR-548m, miR-631, and other microRNAs in lesion tissue and blood.
- miR-155, miR-29, circ-miRNA, and lncRNAs regulate gene expression in TB prognosis.

## Abstract

Tuberculosis, caused by Mycobacterium tuberculosis, is an infectious disease linked to high mortality and can stay in the host cell longer when inactive. Multiple factors are linked to disease prognosis, including microRNAs. It is a diminutive single-stranded RNA that regulates the expression of its target mRNAs. It consists of a brief nucleotide sequence, often 19–25 nucleotides in length, of non-coding RNA. It is also essential for early embryonic development, invasion, cell migration, apoptosis, and cell death. The review aims to analyse the transcriptome characteristics of various miRNAs in the tuberculosis prognosis. However, miR-155, miR-29, circ-miRNA, and lncRNAs regulate gene expression. In TB patients’ serum exosomes, miRNA-146 expression was noticeably higher than in healthy individuals. Drug-resistant tuberculosis was related to miR-548 m, miR-631, miR-328-3p, and miR-let-7e-5p, as well as let-7b-5p, miR-30a-3p, IL-27, and CXCL9/10/11 in TB patients’ lesion tissue and peripheral blood. Therefore, further miRNA research will focus on TB progression.