# A Comparison of Five-Year Survival Rates Between Thermal Ablation and Hepatic Resection for Colorectal Cancer Metastasis to the Liver: A Systematic Review and Meta-Analysis

## TL;DR

This study compares liver resection and thermal ablation for treating liver metastases from colorectal cancer and finds no significant difference in 5-year survival rates.

## Contribution

The study provides a meta-analysis comparing two treatment approaches for colorectal liver metastases.

## Key findings

- No significant difference in 5-year overall survival between liver resection and thermal ablation.
- Higher tumor recurrence in the ablation group compared to resection.
- Similar complication rates between the two treatment approaches.

## Abstract

A significant proportion of colorectal liver metastases (CRLMs) are unresectable. This study compares liver resection with thermal ablation.

The included studies enrolled patients with either resectable or unresectable tumors, depending on tumor characteristics, institutional protocols, and clinical eligibility. All included studies specifically assessed liver metastases from colorectal adenocarcinoma.

The findings of this review found no significant difference in 5-year overall and disease-free survival rates between both approaches (relative risk (RR) = 0.84 (0.54, 1.30), P = 0.35, I2 = 94%) and (RR = 1.00 (0.32, 3.13), P = 0.99, I2 = 89%), respectively. However, tumor recurrence was higher in the ablation group (odds ratio (OR) = 1.66 (1.06, 2.62), P = 0.03, I2 = 10%). Both groups had similar complication rates (OR = 0.34 (0.09, 1.21), P = 0.08, I2 = 84%). GRADE certainty was very low for all outcomes. The study quality was heterogeneous, and the Newcastle-Ottawa scale (NOS) score ranged from 5 to 9, indicating a moderate to high risk of methodological quality.

The broad heterogeneity of the quality of studies limits the evidence of thermal ablation. Given these uncertainties, hepatic resection is currently the preferred approach.