# Rise of the Resistance: A Case of Resistant Shigellosis in an Immunocompetent Female Patient

## TL;DR

This paper reports a case of drug-resistant shigellosis in a healthy woman with no travel history, emphasizing the growing threat of antibiotic resistance.

## Contribution

The novelty lies in documenting resistant shigellosis in an immunocompetent patient without risk factors or recent antibiotic use.

## Key findings

- The patient showed intermediate resistance to fluoroquinolones despite no recent travel or antibiotic use.
- Azithromycin was effective after ciprofloxacin failed, highlighting the need for susceptibility testing.
- The case underscores the increasing prevalence of multidrug-resistant Shigella infections.

## Abstract

Shigellosisis a common enteric infection with updated empiric treatment guidance due to the emergence of resistant isolates. Herein, we describe a case of resistant shigellosis in an immunocompetent female with no recent travel. The patient initially started ciprofloxacin, but due to ongoing gastrointestinal symptoms and intermediate resistance to fluoroquinolones on stool culture, she was later switched to azithromycin. We believe this case demonstrates the looming threat of multidrug-resistant Shigella, even among those without risk factors or recent antibiotic use. This case also highlights the importance of stool culture susceptibility testing.