# Ultra-lightweight uncertainty-aware ensemble for large-scale multi-class medical MRI diagnosis

**Authors:** Sowad Rahman, Fahmid Al Farid, Mahe Zabin, Jia Uddin, Hezerul Abdul Karim

PMC · DOI: 10.3389/fradi.2025.1723272 · Frontiers in Radiology · 2025-12-19

## TL;DR

This paper introduces a compact and efficient model for medical MRI diagnosis that balances accuracy and reliability, suitable for low-resource settings.

## Contribution

The novel UALE model combines lightweight micro-expert networks with uncertainty quantification for efficient and reliable medical MRI diagnosis.

## Key findings

- UALE achieves 69.1% accuracy and 68.3% F1 score with only 0.05M parameters and 0.18 GFLOPs.
- The model's uncertainty quantification enhances clinical trustworthiness and reliability.
- UALE is suitable for low-resource clinical settings due to its compactness and efficiency.

## Abstract

This paper introduces an Ultra-Lightweight Uncertainty-Aware Ensemble (UALE) model for large-scale multi-class medical MRI diagnosis, evaluated on the 2024 Benchmark Diagnostic MRI and Medical Imaging Dataset containing 40 classes and 33,616 images. The model integrates five specialized micro-expert networks, each designed to capture distinct MRI features, and combines them using a confidence-weighted ensemble mechanism enhanced with variance-based uncertainty quantification for robust, reliable predictions. With only 0.05M parameters and 0.18 GFLOPs, UALE achieves high efficiency and competitive performance among ultra-lightweight models with an accuracy of 69.1% and an F1 score of 68.3%. Besides lightweight models, the paper offers an extensive analysis and performance comparison with fifteen state-of-the-art models, discusses various datasets, elaborates on uncertainty estimates pertaining to the clinical trustworthiness of the models and possible clinical deployment, and highlights trade-offs and avenues for future work in economically constrained settings. The extreme compactness and reliability of the UALE affords it unique utility in scalable medical diagnostics suitable for low-resource clinical settings and portable imaging devices, such as rural hospitals.

## Full-text entities

- **Diseases:** fibrosis (MESH:D005355), gliomas (MESH:D005910), Lumbosacral Plexitis (MESH:C537221), skin lesion (MESH:D012871), tumor (MESH:D009369), spinal stenosis (MESH:D013130), edema (MESH:D004487), hemorrhage (MESH:D006470), spinal or neurological disorders (MESH:D009461), spinal disorder (MESH:D013118), disc herniations (MESH:D007405), Dermatomyositis (MESH:D003882), metastases (MESH:D009362), rare diseases (MESH:D035583), meningiomas (MESH:D008579), ischemic stroke (MESH:D002544), UALE (MESH:D058926), cortical malformations (MESH:D054220), multiple sclerosis (MESH:D009103), neurological and systemic disorders (MESH:D009422), Brain Tumor (MESH:D001932)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12757377/full.md

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12757377/full.md

## References

48 references — full list in the complete paper: https://tomesphere.com/paper/PMC12757377/full.md

---
Source: https://tomesphere.com/paper/PMC12757377