# Retroperitoneal multiple giant liposarcoma: a case report

**Authors:** Jiaxin Hou, Qingqiang Yang

PMC · DOI: 10.3389/fsurg.2025.1728768 · Frontiers in Surgery · 2025-12-18

## TL;DR

This paper reports a rare case of multiple large liposarcomas in the retroperitoneum successfully treated with surgery.

## Contribution

The novelty lies in the successful complete resection of massive, multifocal retroperitoneal liposarcomas through multivisceral surgery.

## Key findings

- Multivisceral resection achieved R0 status in a patient with multiple giant retroperitoneal liposarcomas.
- The case demonstrates the feasibility of complete tumor removal despite the tumor's size and multifocal nature.
- Early detection and surgical intervention are critical for managing asymptomatic retroperitoneal liposarcomas.

## Abstract

The retroperitoneal anatomical space is located below the diaphragm and above the pelvic diaphragm, in the potential space between the posterior parietal peritoneum and the abdominal transverse fascia. Retroperitoneal liposarcoma is a common tumor in this region of the body. It typically presents no obvious clinical symptoms in the early stage due to the capaciousness of the area. Usually, however, an increase in tumor volume causes compression of the surrounding tissues and organs, such as intestinal obstruction and urinary obstruction, which leads to prominent symptoms. Primary giant retroperitoneal liposarcoma is a rare clinical entity. A comprehensive review of the literature reveals only a limited number of documented cases, with heterogeneity in their presentation, management, and outcomes. This report presents a case of multiple giant retroperitoneal liposarcomas successfully managed with multivisceral resection achieving R0 status. This case highlights the surgical challenges and feasibility of complete resection even in massive and multifocal tumors.

## Linked entities

- **Diseases:** liposarcoma (MONDO:0003585)

## Full-text entities

- **Diseases:** liposarcoma (MESH:D008080), Retroperitoneal liposarcoma (MESH:C538370), urinary obstruction (MESH:D001748), intestinal obstruction (MESH:D007415), tumor (MESH:D009369)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12756451/full.md

## References

52 references — full list in the complete paper: https://tomesphere.com/paper/PMC12756451/full.md

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Source: https://tomesphere.com/paper/PMC12756451