# Perspectives on Orthology During the Quest for Orthologs

## TL;DR

This paper discusses challenges in identifying orthologous genes, which are crucial for understanding protein functions.

## Contribution

The paper presents eleven new research articles addressing current issues in orthology detection and characterization.

## Key findings

- Highlights ongoing challenges in orthology detection.
- Presents eleven articles on current research in orthologous gene annotation.
- Emphasizes the importance of orthologs in protein function annotation.

## Abstract

This special issue from the Quest for Orthologs community highlights ongoing challenges in detecting and characterizing orthologous genes in the annotation of protein functions. Eleven articles are presented describing ongoing research in this area.