# Intervention strategies for cancer-related sarcopenia: a scoping review

## TL;DR

This review explores effective strategies to treat muscle loss in cancer patients, emphasizing the need for combined approaches.

## Contribution

The study categorizes interventions for cancer-related sarcopenia and highlights the importance of integrated treatment strategies.

## Key findings

- Eighteen randomized controlled trials were analyzed to evaluate intervention strategies for cancer-related sarcopenia.
- Four types of interventions were identified: nutritional, exercise, pharmacological, and multidisciplinary.
- Integrated approaches combining multiple strategies are recommended to improve patient outcomes.

## Abstract

This article systematically reviewed intervention strategies for cancer-related sarcopenia (CRS), providing evidence for researchers to develop targeted treatments.

PubMed, Embase, Web of Science, and the Cochrane Library were searched for studies between 2015 and 2025, followed by literature screening and content analysis.

A total of 3,566 articles were initially identified, and 18 randomized controlled trials (published between 2016 and 2025; sample sizes ranging from 15 to 232) were ultimately included. CRS interventions were categorized into four types: nutritional, exercise, pharmacological, and multidisciplinary.

A CRS intervention needs an integrated approach that combines nutrition, exercise, pharmacology, and a multidisciplinary team (MDT) to improve patients’ functional outcomes and quality of life. Future research should focus on precision approaches and translational medicine.