# The inflammation saga: Breakthrough nutritional insights for poultry

**Authors:** Rajesh Jha, Doug Korver, Woo Kyun Kim, Leon Marchal, Kirsty Gibbs, John Halley

PMC · DOI: 10.1016/j.psj.2025.106200 · Poultry Science · 2025-12-05

## TL;DR

This paper discusses new nutritional strategies to manage gut inflammation in poultry, aiming to improve health and productivity.

## Contribution

The paper introduces actionable nutritional approaches to mitigate gut inflammation in poultry through targeted feed formulation.

## Key findings

- Dietary fiber can act as both an irritant and a modulator of gut immunity.
- Amino acids like threonine and glutamine support mucosal repair and immune function.
- Mineral chelation improves bioavailability while reducing inflammation.

## Abstract

This symposium offered a broader perspective on gut inflammation in poultry. It covered the basic factors that trigger gut inflammation, their potential effects on performance and health, and potential strategies to manage inflammation and mitigate its adverse effects. Gut inflammation has emerged as a critical determinant of health and performance in modern poultry production. A focus was placed on key nutritional factors that influence gut integrity and immune activation, including the pro- and anti-inflammatory roles of specific feed components. The role of dietary fiber was discussed, emphasizing its dualistic effects as both a potential irritant and a modulator of microbial populations and immune functions. The symposium also discussed the roles of amino acids such as threonine, glutamine, and arginine, which aid in mucosal repair and immune modulation. Additionally, the impact of mineral chelation, particularly involving zinc and copper, was discussed in the context of enhancing mineral bioavailability while minimizing oxidative and inflammatory responses. Ultimately, the symposium explored a practical approach to managing gut inflammation in commercial poultry operations, emphasizing the importance of early nutritional interventions and targeted feed formulation and nutrition strategies. Lastly, it was concluded that by integrating current scientific evidence with practical insights, poultry nutritionists and industry stakeholders should employ multiple approaches based on actionable knowledge to optimize gut health and reduce inflammation, thereby enhancing bird performance and the sustainability of the poultry industry.

## Linked entities

- **Chemicals:** threonine (PubChem CID 205), glutamine (PubChem CID 738), arginine (PubChem CID 232), zinc (PubChem CID 23994), copper (PubChem CID 23978)

## Full-text entities

- **Diseases:** Gut inflammation (MESH:D007249)
- **Chemicals:** threonine (MESH:D013912), copper (MESH:D003300), zinc (MESH:D015032), glutamine (MESH:D005973)

## Full text

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## References

72 references — full list in the complete paper: https://tomesphere.com/paper/PMC12756012/full.md

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Source: https://tomesphere.com/paper/PMC12756012