# Emerging analytical techniques for lipid profiling in food products: insights into processing effects and quality control

**Authors:** Deepika Kathuria, Sonal Aggarwal, Akanksha Negi, Riya Barthwal, Aroma Joshi, Narpinder Singh

PMC · DOI: 10.1016/j.fochx.2025.103360 · Food Chemistry: X · 2025-12-03

## TL;DR

This paper reviews new lipid analysis methods, like lipidomics and mass spectrometry, to better understand how food processing affects lipid quality and safety.

## Contribution

The paper highlights the use of lipidomics and AI in analyzing food lipids and their response to processing.

## Key findings

- Mass spectrometry-based lipidomics can detect lipid changes during food processing.
- AI systems can link oil processing parameters to quality metrics.
- Lipidomics provides insights into lipid oxidation and food authenticity.

## Abstract

Lipids are essential components of foods which include fatty acids, glycolipids, sphingolipids, sterols, vitamin D, isoprenoids, etc. It possesses bioactive properties that exhibit desirable impact on human health. However, understanding the complexity of food lipids, requires sophisticated analytical methods capable of capturing their full spectrum. Lipidomics (LIP), an emerging omics field derived from metabolomics focuses on the complete analysis of lipid molecules within food matrices. Mass spectrometry (MS)-based LIP, exhibit great potential for analysing food lipids. The present review discusses the application of LIP in characterizing lipid metabolites in food, including how food processing, cooking, and storage, influence lipid profiles. Advancement in MS-based LIP enabled the detection of lipid alterations, along with ensuring food quality, authenticity, and safety. Future trends suggest further advancements in MS and separation techniques and application of Large Language Models will emerge as powerful tools in supporting oil processing research and industry practices. These techniques offered innovative predictions for mining significant information from lipidomic related large volumes of scientific and technical literature that will expand the application of LIP, providing deeper insights into lipid metabolism as well as understanding lipids in relation to health and nutrition.

•Food lipid include fatty acids, glycolipids, sphingolipids, sterols, etc•Lipidomics involve application of advanced mass spectrometry techniques•Provide insights into food lipid complexity, lipid oxidation during processing•Advance AI-powdered system relates oil processing parameters to quality metrics

Food lipid include fatty acids, glycolipids, sphingolipids, sterols, etc

Lipidomics involve application of advanced mass spectrometry techniques

Provide insights into food lipid complexity, lipid oxidation during processing

Advance AI-powdered system relates oil processing parameters to quality metrics

## Full-text entities

- **Chemicals:** isoprenoids (MESH:D013729), oil (MESH:D009821), fatty acids (MESH:D005227), sterols (MESH:D013261), Lipids (MESH:D008055), vitamin D (MESH:D014807), glycolipids (MESH:D006017), sphingolipids (MESH:D013107)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12755995/full.md

## References

179 references — full list in the complete paper: https://tomesphere.com/paper/PMC12755995/full.md

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Source: https://tomesphere.com/paper/PMC12755995