# Dimephosphon Radioprotective Properties on the Model of Radiation Injury In Vivo

## TL;DR

This study shows that Dimephosphon can protect healthy tissue from radiation damage in mice by boosting antioxidant levels.

## Contribution

The study demonstrates Dimephosphon's local radioprotective effect and its impact on key antioxidant metabolites.

## Key findings

- Dimephosphon reduced radiation-induced injury in the intestinal epithelium and splenic capsule of mice.
- Metabolomic analysis showed increased levels of antioxidant metabolites like alpha-tocopherol and nicotinamide riboside.

## Abstract

Radiation therapy is a commonly used cancer treatment modality. However, its
application is limited because of its toxicity to healthy tissue. The search
for effective radioprotective agents remains one of the key goals of radiation
oncology and radiobiology. This study focuses on experimental modeling of
radiation injury in animals and the investigation of Dimephosphon
radioprotective properties, a drug exhibiting anti-acidotic, antitumor, and
antioxidant activities. It was shown that 14-day administration of the drug at
a dose of 750 mg/kg after single-dose (5 Gy) irradiation of CD-1 mice resulted
in a local radioprotective effect, reducing the severity of the
radiation-induced injury to the intestinal epithelium and splenic capsule. The
results of metabolomic screening revealed that the levels of the key
metabolites responsible for antioxidant properties such as alpha-tocopherol,
nicotinamide riboside, N-carbamoyl-L-aspartate, and adenylosuccinate were
significantly increased, indicating that the Dimephosphon drug provides
enhanced antioxidant protection.