Corrigendum: Hidden in Plain Sight: High Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality
Caner Süsal, Bernd Döhler, Erol Demir, Walaa Ibrahim, Medhat Askar
TL;DR
High tacrolimus metabolism in kidney transplant patients is linked to higher transplant failure and infection-related deaths, with strategies like diltiazem and steroid tapering potentially improving outcomes.
Contribution
The study identifies high tacrolimus metabolism as a significant risk factor for transplant failure and infection mortality, using the largest dataset to date.
Findings
25.2% of kidney transplants had low tacrolimus concentration-dose-ratio (CDR), linked to a 2.80 hazard ratio for poor outcomes.
Low CDR was associated with a 63% increase in infection-related mortality.
Strategies like diltiazem co-medication and steroid tapering may improve outcomes in high-risk groups.
Abstract
High tacrolimus metabolism is linked to increased kidney transplant failure and infection-related mortality. The study analyzed 21,865 kidney transplants from 2000 to 2019, the largest to date. About 25.2% had a low concentration-dose-ratio (CDR), predicting poor outcomes with a hazard ratio up to 2.80 and a 63% increase in infection-related mortality. Higher risk groups include females, young individuals, and those with CYP3A5*1A. Strategies like diltiazem co-medication and steroid tapering may improve long-term outcomes in patients with low CDR. Conducted by Caner Süsal, published in Transplant International.
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Taxonomy
TopicsRenal Transplantation Outcomes and Treatments · Neurological Complications and Syndromes · Erythropoietin and Anemia Treatment
In the published article, there was an error in the article title. Instead of “Hidden in Plain Sight: Low Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality”, it should be “Hidden in Plain Sight: High Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality”.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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