# Immune Thrombocytopenia and Type 1 von Willebrand Disease in a Patient With a Femoral Fracture: A Case Report

**Authors:** André Ferreira, André Roberto

PMC · DOI: 10.7759/cureus.98215 · Cureus · 2025-12-01

## TL;DR

This case report details a patient with two bleeding disorders who required urgent surgery and the challenges of managing their condition during anesthesia.

## Contribution

The paper highlights the unique anesthetic management challenges in a patient with coexisting immune thrombocytopenia and von Willebrand disease.

## Key findings

- The patient had immune thrombocytopenia and von Willebrand disease, increasing surgical bleeding risk.
- Perioperative management required careful coordination to address both bleeding disorders.
- The case emphasizes the importance of tailored anesthetic strategies for complex comorbidities.

## Abstract

This article describes the case of a complex medical patient with immune thrombocytopenia (ITP) and von Willebrand disease (vWD), among other comorbidities, who underwent urgent orthopedic surgery and discusses the specificities of the perioperative anesthetic management of these bleeding disorders. Immune thrombocytopenia is an acquired autoimmune condition characterized by a diminished platelet count due to immune destruction. vWD is the most common inherited bleeding disorder, in which there is a defect of von Willebrand factor, a fundamental component of the hemostatic process. By compromising primary hemostasis, both conditions carry an important hemorrhagic risk in surgical patients, which is compounded by their coexistence.

## Linked entities

- **Diseases:** immune thrombocytopenia (MONDO:0002048), von Willebrand disease (MONDO:0019565)

## Full-text entities

- **Genes:** VWF (von Willebrand factor) [NCBI Gene 7450] {aka F8VWF, VWD}
- **Diseases:** vWD (MESH:D014842), inherited bleeding disorder (MESH:D025861), autoimmune condition (MESH:D001327), bleeding (MESH:D006470), ITP (MESH:D016553), Type 1 von Willebrand Disease (MESH:D056725), Femoral Fracture (MESH:D005264)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

33 references — full list in the complete paper: https://tomesphere.com/paper/PMC12754686/full.md

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Source: https://tomesphere.com/paper/PMC12754686