This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTED: Gravina et al. The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models. Cancers 2019, 11, 1604
Giovanni Luca Gravina, Andrea Mancini, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Simona Pompili, Flora Vitale, Stefano Martellucci, Francesco Marampon, Vincenzo Mattei, Leda Biordi, David Sherris, Claudio Festuccia

Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsPI3K/AKT/mTOR signaling in cancer · Cancer-related gene regulation · Angiogenesis and VEGF in Cancer
The journal retracts the article, “The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models” [1], cited above.
Following publication, concerns were brought to the attention of the Editorial Office regarding the duplication or partial overlap between a sub-image in Figure 6 [1] and sub-images in Figure 5 in another publication [2] with partially overlapping authorship.
Adhering to our standard procedure, an investigation was conducted by the Editorial Office and the Editorial Board that confirmed two partial overlaps and one duplication between Figure 6 in this publication [1] and sub-figures included in Figure 6 in another paper [2]. While the authors provided replacement images during the investigation, the Editorial Board found the explanations regarding the duplicated data insufficient to warrant a correction. Consequently, the Editorial Board has lost confidence in the reliability of the findings and decided to retract this publication [1], as per MDPI’s retraction policy (https://www.mdpi.com/ethics#_bookmark30).
This retraction was approved by the Editor-in-Chief of the Cancers journal.
The authors did not provide a comment on this decision.
The corresponding author, Claudio Festuccia, takes full responsibility for the concerns raised and clarifies that the other co-authors were not directly involved in the duplication of the figures in question.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Gravina G.L. Mancini A. Colapietro A. Delle Monache S. Sferra R. Pompili S. Vitale F. Martellucci S. Marampon F. Mattei V. RETRACTED: The Brain Penetrating and Dual TORC 1/TORC 2 Inhibitor, RES 529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models Cancers 201911160410.3390/cancers 1110160431640252 PMC 6826425 · doi ↗ · pubmed ↗
- 2Gravina G.L. Mancini A. Colapietro A. Delle Monache S. Sferra R. Vitale F. Cristiano L. Martellucci S. Marampon F. Mattei V. The Small Molecule Ephrin Receptor Inhibitor, GLPG 1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models Cancers 20191135910.3390/cancers 1103035930871240 PMC 6468443 · doi ↗ · pubmed ↗
