# Epithelial to Mesenchymal Transition Transcriptional Regulator ZEB1 in Liver Cancer: Oncogenic Roles and Therapeutic Potential

## TL;DR

This paper explores how ZEB1, a key regulator of cell transition, contributes to liver cancer and how targeting it could lead to better treatments.

## Contribution

The paper provides new insights into ZEB1's role in liver cancer progression and its potential as a therapeutic target.

## Key findings

- ZEB1 is overexpressed in liver tumors like HCC and CCA.
- High ZEB1 levels correlate with advanced disease and poor survival in liver cancer patients.

## Abstract

Zinc finger E-box binding homeobox 1 (ZEB1) is a member of the zinc finger homeodomain transcription factor family, with a pivotal role in regulating the epithelial to mesenchymal transition (EMT) process. Increasing evidence suggests that ZEB1 is overexpressed in liver tumors, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), and it correlates with advanced disease features and reduced overall survival. Here, we examine ZEB1 molecular functions, regulatory networks and contribution to tumorigenesis. We also discuss the emerging therapeutic strategies and future research directions aimed at targeting the ZEB1 molecular network to improve the outcome of liver cancer patients.