# Recent Progress of Magnetic Nanomaterials with Enhanced Enzymatic Activities in Antitumor Therapy

## TL;DR

This review discusses recent advances in magnetic nanomaterials that mimic enzymes to enhance cancer therapy through catalytic reactions and electromagnetic effects.

## Contribution

The paper provides a comprehensive overview of recent developments in magnetic nanomaterials with enhanced enzymatic activities for antitumor therapy.

## Key findings

- Magnetic nanomaterials can be designed to exhibit magneto-thermal, magneto-mechanical, and magneto-electric effects for cancer treatment.
- Nanozymes and immobilized enzymes show promise in catalytic reactions triggered by electromagnetic fields.
- Innovative magnetic nanomaterials respond to X-rays and ultrasounds to kill cancer cells.

## Abstract

Magnetic nanomaterials with enhanced enzymatic activities have garnered significant attention from researchers worldwide. Magnetic nanomaterials, including nanozymes and immobilized enzymes, can initiate specific catalytic reactions in the diseased microenvironment for cancer treatment. In this review, we aim to present the significant advancements in synthesizing various types of magnetic nanomaterials with enhanced enzymatic activities and their antitumor therapy applications in the past five years. We first show the representative magnetic nanomaterials and elucidate their fundamental mechanisms related to magnetic properties and electromagnetic effects (such as magneto-thermal, magneto-mechanical, and magneto-electric effects). Secondly, we introduce magnetic nanozymes and magnetic immobilized enzymes and discuss the creative methods allowing the enzymatic activities of nanomaterials to be remotely enhanced by various electromagnetic effects. We also discuss some innovative magnetic nanomaterials that exhibit unique responsiveness to external energies (such as X-rays and ultrasounds) for killing cancer cells. Finally, we address future research suggestions in rationally designing advanced magnetic nanomaterials with remote increased enzymatic activities and discuss challenges and opportunities for efficient cancer therapy.