# Evaluation of Aminoglycoside Dosing Regimens Adjusted for Renal Function and In Vitro Susceptibility Test Interpretive Criteria for Enterobacterales and Pseudomonas aeruginosa: Brief Summary

## TL;DR

This paper evaluates aminoglycoside dosing for kidney function and antibiotic resistance in certain bacteria.

## Contribution

It proposes new dosing regimens and reevaluates susceptibility test criteria for better treatment outcomes.

## Key findings

- Pharmacometric analyses support dosing regimens adjusted for renal function.
- Susceptible breakpoints are recommended for extended-interval aminoglycoside use.
- The study suggests revised USCAST interpretive criteria for Enterobacterales and Pseudomonas aeruginosa.

## Abstract

The results of pharmacometric analyses for aminoglycosides were used to support recommendations for dosing regimens adjusted for renal function and a reassessment of the United States Committee on Antimicrobial Susceptibility Testing susceptibility test interpretive criteria for Enterobacterales and Pseudomonas aeruginosa. Susceptible and susceptible-based on therapeutic drug monitoring breakpoints are recommended for extended-interval amikacin, gentamicin, and tobramycin dosing regimens, thus representing adaptable treatable approaches.

A brief summary of the pharmacometric analyses for aminoglycosides used to support recommendations for dosing regimens adjusted for renal function and a reassessment of the USCAST STIC for Enterobacterales and Pseudomonas aeruginosa is provided. Susceptible and susceptible based on therapeutic drug monitoring breakpoints are recommended for extended interval amikacin, gentamicin, and tobramycin dosing regimens.