Research Progress on the Biological Activities and Clinical Applications of Pseudoprotodioscin
Jie Li, Senling Feng, Zhenya Du, Zhuzhu Wu, Wei Mo, Xiaoming Chen, Jiancong Wu, Yanming Lin, Chunsong Cheng, Xinbing Sui, Qibiao Wu
TL;DR
This paper reviews the biological activities and clinical potential of pseudoprotodioscin (PPD), a plant-derived compound with anticancer and protective effects, but low bioavailability.
Contribution
The paper compiles and analyzes recent studies on PPD's pharmacological effects and suggests strategies to improve its drug delivery.
Findings
PPD shows anticancer, anti-inflammatory, hepatoprotective, and cardioprotective effects.
PPD has low bioavailability (5.7%) in rats, suggesting a need for improved drug delivery systems.
Chinese patent medicines containing PPD have promising clinical applications.
Abstract
Background: Pseudoprotodioscin (PPD) is a prominent active steroidal saponin isolated from plants of the genus Dioscorea. Investigations have shown that PPD exhibits considerable biological activity and has great clinical potential. Methods: Dioscorea plants and pseudoprotodioscin were used as search terms for study retrieval. Studies involving PPD were collected from a wide range of databases, including China National Knowledge Infrastructure, PubMed, Web of Science, and Elsevier, as well as relevant scientific websites. Results: PPD possesses multiple bioactive properties, such as anticancer, anti-inflammatory, hepatoprotective, and cardioprotective effects. Pharmacokinetic studies in rats indicated that PPD undergoes rapid excretion and has low bioavailability (5.7%), which need to develop a more effective drug delivery system to modify, such as lipid-based nanoparticles.…
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Taxonomy
TopicsTraditional Chinese Medicine Analysis · Ginseng Biological Effects and Applications · Plant-based Medicinal Research