A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes
Lisa Kurz, Mechthild Lütge, Angelina De Martin, Hung-Wei Cheng, Elina Bugar, Yves Stanossek, Samuel Meili, Joshua D. Brandstadter, Ivan Maillard, Lucas Onder, Burkhard Ludewig
TL;DR
This study shows that fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes come from a shared progenitor.
Contribution
The discovery of a common CCL19-expressing progenitor for fibroblastic reticular and vascular smooth muscle cells in lymph nodes.
Findings
Fibroblastic reticular cells and vascular smooth muscle cells share a proliferating CCL19-expressing embryonic progenitor.
LTβR-dependent lineages give rise to fibroblastic reticular cells in lymph node compartments.
Vascular smooth muscle cells develop independently from the same progenitor but remain closely related.
Abstract
The study by Kurz et al. elucidates the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors and highlights the close lineage relationship of the progeny in the perivascular niche. The interaction of immune cells in the lymph node microenvironment depends on the infrastructure and molecular cues provided by fibroblastic reticular cells (FRCs). In addition, concentric layers of still poorly defined mural cells, including vascular smooth muscle cells (VSMCs), are involved in positioning and regulating immune cell interactions in different lymph node compartments. Using time-resolved single-cell transcriptomics, combined with cell fate mapping and high-resolution confocal microscopy, we found that lymph node FRCs and VSMCs share a proliferating, CCL19-expressing embryonic progenitor. Trajectory…
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Taxonomy
TopicsSingle-cell and spatial transcriptomics · Immune cells in cancer · Cell Adhesion Molecules Research