# Peucedanum japonicum-Derived Exosome-like Nanovesicles Alleviate Contact Dermatitis

## TL;DR

This study shows that nanovesicles from Peucedanum japonicum reduce inflammation in a mouse model of contact dermatitis.

## Contribution

The novel contribution is the identification of plant-derived exosome-like nanovesicles as a potential treatment for inflammatory skin diseases.

## Key findings

- PjELNs reduced ear swelling and histopathological damage in a mouse model of contact dermatitis.
- PjELNs decreased infiltration of inflammatory immune cells, especially neutrophils.
- PjELNs downregulated pro-inflammatory cytokines like CXCL2 and IL-1β.

## Abstract

Contact dermatitis is a common inflammatory skin disorder triggered by exposure to allergens or irritants and characterized by erythema, swelling, and immune cell infiltration. In this study, we investigated the anti-inflammatory effects of exosome-like nanovesicles derived from Peucedanum japonicum Thunb. (PjELNs) using a 2,4,6-trinitrochlorobenzene (TNCB)-induced mouse model of contact dermatitis. Intraperitoneal administration of PjELNs markedly reduced ear swelling and histopathological damage and decreased infiltration of inflammatory immune cells, particularly neutrophils. Moreover, PjELNs downregulated the expression of key pro-inflammatory cytokines, including CXCL2 and IL-1β, in the affected tissue. These findings indicate that PjELNs alleviate contact dermatitis-associated inflammation and suggest their potential as a novel plant-derived therapeutic modality for inflammatory skin diseases.