Magnetic drug-loaded microbubbles for treating lower limb venous thrombosis under controllable rotating magnetic field
Yu-Ming Huang, Cheng-Rang Liu, Yi-Qi Xu, Chao Cao, Zhen-Gan Huang, Hong-Wen Fei, Yue-Shan Huang
TL;DR
This study introduces magnetic microbubbles loaded with a clot-dissolving drug to treat leg blood clots using a rotating magnetic field, showing improved effectiveness in both lab and animal tests.
Contribution
A novel magnetic drug delivery system using microbubbles and a rotating magnetic field for enhanced thrombolysis in acute venous thrombosis.
Findings
Magnetic microbubbles achieved 25% thrombolysis in vitro under a 1.5 mT rotating magnetic field.
In vivo experiments in rabbits showed restored blood flow and elevated D-dimer levels, indicating effective clot dissolution.
The system reached a maximum proUK encapsulation efficiency of 56.65% at 7.5 mg/mL concentration.
Abstract
This study aimed to develop a poly (lactic-co-glycolic acid) (PLGA)-based magnetic loaded iron oxide (Fe3O4) and single-chain urokinase-type plasminogen activator (proUK) for enhancing thrombolysis under a controlled rotating magnetic field, specifically targeting acute lower limb venous thrombosis. Acute thrombotic disorders are significant health threats, however, the exploration of magnetic actuation as a treatment for acute thrombosis has been limited. Magnetic microbubbles were prepared using a double emulsion method, loaded with Fe3O4 nanoparticles and proUK. The microbubble characteristics were analyzed through chemical, physical, and biological related technologies. Fe3O4 nanoparticle loading was confirmed by X-ray diffraction, and the encapsulation efficiency of the magnetic microbubbles was determined using an ELISA kit and colorimetric assay, reaching a maximum of 56.65%…
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Taxonomy
TopicsDiagnosis and Treatment of Venous Diseases · Ultrasound and Hyperthermia Applications · Venous Thromboembolism Diagnosis and Management