ERP Biomarkers of Auditory–Visual Distraction in Aging and Cognitive Impairment

TL;DR

This study identifies brain activity patterns linked to distraction in aging and cognitive diseases like Alzheimer's, which could help detect early signs of cognitive decline.

Contribution

The study introduces ERP biomarkers of auditory-visual distraction as potential early indicators of cognitive impairment and aging.

Findings

Older adults showed increased N1-enhancement and reduced P3a and RON amplitudes, indicating age-related distraction susceptibility.

MCI and AD patients exhibited further ERP abnormalities, suggesting impaired attention orientation and reorientation.

Reduced P3a amplitude and delayed RON correlated with executive dysfunction and memory deficits.

Abstract

Background/Objectives: Distraction is a form of impaired selective attention that becomes more pronounced with normal aging and in pathological conditions such as mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Event-related potentials (ERPs) provide sensitive, time-resolved measures of neural mechanisms underlying distractibility. This study aimed to identify age- and disease-related ERP signatures of auditory–visual distraction as potential functional biomarkers for cognitive decline. Methods: Forty-six participants were enrolled, including young controls (Y), healthy older controls (O), individuals with MCI, and individuals with AD. Participants performed cross-modal interference tasks in which irrelevant auditory distracting sounds were paired with a relevant visual discriminating task. The distraction potential was quantified as the difference between ERP responses to novel distractors and standard stimuli, focusing on three core components: N1-enhancement, P3a, and reorienting negativity (RON). Behavioral measures (accuracy, reaction time, miss responses) were also assessed. Results: Compared to Y, O showed increased N1-enhancement and reduced P3a and RON amplitudes, consistent with age-related susceptibility to distraction. Patients with MCI and AD exhibited further abnormalities, including diminished P3a and altered RON responses, suggesting impaired orientation and reorientation of attention. Behavioral distraction effect was observed in all groups, with no significant difference between groups. ERP–cognition correlations indicated that reduced P3a amplitude and delayed RON were associated with executive dysfunction and memory deficits. Conclusions: ERP signatures of distraction, particularly altered P3a and RON components, differentiate normal aging from pathological decline and may serve as functional biomarkers for early detection of MCI and AD. These findings highlight the translational potential of distraction paradigms in clinical assessment of aging-related cognitive impairment.

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