Longitudinal Cerebral Structural, Microstructural, and Functional Alterations After Brain Tumor Surgery for Early Detection of Recurrent Tumors

TL;DR

This study explores how advanced MRI techniques can detect brain tumor recurrence earlier than traditional methods.

Contribution

The study introduces the use of DTI and rsfMRI for early detection of tumor recurrence before visible changes on standard MRI.

Findings

DTI showed early directionality loss and FA reduction before T1w or FLAIR changes were visible.

Functional connectivity alterations were detected at tumor recurrence sites.

One patient showed FA decrease at tumor site before morphological changes were detectable.

Abstract

Background: Early detection of recurrent brain tumors after malignant glioma surgery is a challenge in imaging-based assessment of glioma. Objective: The aim of this case series is to investigate whether there are signs for an improvement in the early detection of recurrent tumors using multiparametric magnetic resonance imaging (MRI) after glioma surgery. Methods: An MRI protocol was used with high-resolution fluid-attenuated inversion recovery (FLAIR), diffusion tensor imaging (DTI), resting state functional MRI (rsfMRI), and contrast-enhanced high resolution T1-weighted (T1w). Longitudinal multiparametric MRI was performed in six patients with glioblastoma with one complete scan before surgery, one scan after surgery and at least two follow-up scans. A total of 27 complete multiparametric MRI data sets were available. Results: DTI analysis at the localizations of recurrent tumors showed early directionality loss in DTI by fractional anisotropy (FA) reduction accompanied by FLAIR hyperintensities before hyperintensities in contrast enhanced T1w were visible. One out of six patients showed a regional FA decrease at the localization of the recurrent tumor at a point of time even when the morphological T1w- and FLAIR images did not demonstrate any detectable changes. Functional connectivity alterations in a corresponding network could also be detected at the localizations of the recurrent tumor. Conclusions: In addition to routine T2w FLAIR and contrast enhanced T1w, DTI and rsfMRI might complement information for the early detection of recurrent malignant glioma. Prospective studies at larger scale are needed with respect to potential of DTI and rsfMRI for early recurrent tumor detection.

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