The ART of Embryo Selection: A Review of Methods to Rank the Most Competent Embryo(s) for Transfer to Optimize IVF Success

TL;DR

This paper reviews methods used to select the best embryos for transfer in IVF to improve success rates.

Contribution

It provides a comprehensive review of conventional and emerging embryo selection techniques in ART.

Findings

Morphological, genetic, and developmental indicators are key factors in embryo selection.

Emerging technologies offer new tools for evaluating embryos with high implantation potential.

The optimal selection method may vary depending on individual patient factors.

Abstract

Within the field of assisted reproductive technologies (ARTs), embryologists regularly face the critical task of identifying embryos with the highest likelihood of implantation and survival. To help aid and standardize this practice, many embryo selection strategies have been developed to give the best chance of pregnancy success. Over the years, there has been a large increase in experimental studies conducted within this area of research. This increase has allowed for the formation of significant and plausible theories of embryo development, especially in cases where the most prominent factors seem identical. These advancements have both expanded the typical process of traditional treatments and have even paved the way for new techniques. The exact combination of all these relevant factors has not been fully elucidated into a single all-encompassing scheme for embryo decision. Morphological, genetic, and developmental indicators are well-studied individually, but the exact methods that should be prioritized in each scenario may change with respect to an individual patient. Deciding whether factors like age, egg quality, lifestyle choices, or previous medical history should alter methods of embryo ranking can result in conflict, especially in the case where a choice is being made between two similar embryos. This article reviews the conventional methods along with emerging technologies that provide the tools for embryologists to evaluate and rank embryos with high implantation potential (HIP). By showcasing these methods, including their respective benefits and drawbacks, this article provides information to allow clinicians to make effective decisions by integrating multiple approaches to embryo selection.

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