# Applications of Fibronectin in Biomedicine and Cosmetics: A Review

## TL;DR

This review explores how fibronectin, a key protein in the body's connective tissue, is used in medicine and cosmetics to support tissue repair and skin health.

## Contribution

The paper provides a comprehensive overview of fibronectin's biomedical and cosmetic applications, emphasizing its role in tissue regeneration and skin care.

## Key findings

- Fibronectin supports tissue structure and cellular signaling, making it important in regenerative medicine.
- FN is a functional component in biomedical materials and a key ingredient in cosmetic anti-aging treatments.
- The review highlights challenges in FN research, such as protein production and peptide design.

## Abstract

Fibronectin (FN) is a key mechanoresponsive glycoprotein within the extracellular matrix (ECM) that contributes to the assembly of a dynamic fibrillar network that is important for maintaining tissue structure and mediating cellular signaling. In this review, we delineate the molecular mechanisms underlying FN’s role in barrier restoration, ECM remodeling, and stem cell niche regulation, functions that inform its applications in both regenerative medicine and cosmetic science. In biomedical contexts, FN is recognized as a valuable biomarker for numerous diseases, a promising therapeutic target, and a functional component of biomedical material matrices. FN is involved throughout the skin repair process, making it a physiologically active ingredient for cosmetic anti-aging treatments, alleviating sensitive skin conditions, and enhancing cutaneous immunity. This review also addresses significant translational challenges associated with FN research, including recombinant protein production and rational peptide design, and suggests avenues for future work. Ultimately, studies on FN highlight the complexity of ECM biology and lay the groundwork for innovative approaches to advancing human health and developing new cosmetic treatments.