# A Computational Model of the Respiratory CPG for the Artificial Control of Breathing

## TL;DR

Researchers developed a computational model of the PreBotzinger Complex to simulate and control breathing rhythms in real time.

## Contribution

A novel computational model of the PreBötC with 1000 neurons that emulates respiratory CPG behavior and real-time chemoreception.

## Key findings

- The model produced eupneic breathing at 0.22 Hz and responded rapidly to simulated hypercapnia.
- Parallelized computing enabled real-time closed-loop simulations of the respiratory network.
- Asynchronous neurons in the model successfully replicated chemoreception-driven breathing modulation.

## Abstract

The human respiratory Central Pattern Generator (CPG) is a complex and tightly regulated network of neurons responsible for the automatic rhythm of breathing. Among the brain nuclei involved in respiratory control, excitatory neurons within the PreBotzinger Complex (PreBötC) are both necessary and sufficient for generating this rhythmic activity. Although several models of the PreBötC circuit have been proposed, a comprehensive analysis of network behavior in response to physiologically relevant external inputs remains limited. In this study, we present a computational model of the PreBötC consisting of 1000 excitatory neurons, divided into two functional subgroups: the rhythm-generating population and the pattern-forming population. To enable real-time closed-loop simulations, we employed parallelized multi-process computing to accelerate network simulation. The network, composed of asynchronous neurons, could produce bursting activity at a eupneic breathing frequency of 0.22 Hz, which could also reproduce the rapid and stable chemoreception of breathing activated in response to hypercapnia. Additionally, it successfully replicated rapid and stable respiratory responses to elevated carbon dioxide levels (hypercapnia), mediated through simulated chemoreception. External inputs from a carbon dioxide sensor were used to modulate the network activity, allowing the implementation of a real-time respiratory control system. These results demonstrate that a network of asynchronous, non-bursting neurons can emulate the behavior of the respiratory CPG and its modulation by external stimuli. The proposed model represents a step toward developing a closed-loop controller for breathing regulation.