Full-Field Electroretinographic Evaluation of a Case With Benign Lobular Inner Nuclear Layer Proliferations of the Retina

TL;DR

This paper reports a case of a retinal tumor called BLIP in a child, showing that retinal function remains normal despite the tumor.

Contribution

First full-field electroretinography (ERG) study in a patient with BLIP, demonstrating preserved retinal function.

Findings

Multimodal imaging confirmed typical intraretinal BLIP lesions.

Full-field ERG showed preserved scotopic and photopic responses.

Retinal function appears intact in BLIP despite structural abnormalities.

Abstract

Benign lobular inner nuclear layer proliferation (BLIP) is a newly recognized retinal tumor defined by a benign, non‐progressive lesion confined to the inner nuclear layer. Although several cases have been reported worldwide, its functional impact on the retina remains unclear, as prior studies have focused mainly on structural imaging. We report a seven-year-old Japanese boy with BLIP associated with congenital hypertrophy of the retinal pigment epithelium (CHRPE). Multimodal imaging revealed typical intraretinal lesions, and full-field electroretinography (ERG) demonstrated preserved scotopic and photopic responses. To our knowledge, this is the first report of full-field ERG performed in a patient with BLIP, showing that overall retinal function can remain intact.

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