Chaperonins in Hepatocellular Carcinoma: Unveiling Their Role in Tumor Proliferation and Immune Modulation Through Multiomics Analysis
Shou-hua Wang, Feng-ya Lv, Yuan-jie Liu, Jie-pin Li, Jia-qi Hao, Hong-hua Wang
TL;DR
This study explores how chaperonins, especially CCT6B, contribute to liver cancer progression and immune response using multiomics data.
Contribution
The study reveals novel roles of chaperonins, particularly CCT6B, in HCC proliferation and immune modulation through multiomics analysis.
Findings
CCT6B is overexpressed in HCC and linked to poor patient prognosis.
CCT6B promotes tumor cell proliferation and M2 macrophage infiltration via CCL20 signaling.
Chaperonin expression correlates with β-catenin activation in HCC.
Abstract
Chaperonins are crucial regulators of tumor biology by controlling the stability and function of oncogenic and tumor‐suppressor proteins, influencing various tumorigenic signaling pathways. Although chaperonins have been widely discussed in various cancers, including hepatocellular carcinoma (HCC), the complex mechanisms by which they contribute to HCC progression remain insufficiently explored and require further investigation. Based on data from public databases, we screened chaperonin members from the Human Genome Organisation (HUGO) Gene Nomenclature Committee (HGNC) database. The screened genes were subjected to differential expression analysis, survival analysis, clinical correlation, and univariate Cox regression. Results were validated using single‐cell RNA (scRNA) and spatial transcriptomics (ST) data. Functional enrichment and in vitro assays were also performed.…
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Taxonomy
TopicsHeat shock proteins research · Protein Structure and Dynamics · Clusterin in disease pathology