Spatially Resolved Ion Sensing by Voltammetric Ion Transfer Microscopy
Gabriel J. Mattos, Justine A. Rothen, Thomas J. Cherubini, Eric Bakker
TL;DR
A new method for rapidly mapping ion concentrations in solution with high spatial resolution using a fluorescence microscope and ion transfer principles.
Contribution
Introduces a high-frequency, label-free chemical mapping technique for optically silent ionic species with micrometer resolution.
Findings
The method captures concentration maps of millions of pixels in seconds using a conventional fluorescence microscope.
The technique is demonstrated with tetraethylammonium to map diffusional mixing of solution streams.
The approach uses a single sensing film to achieve spatially resolved ion sensing.
Abstract
The visualization and mapping of ionic species in solution and near surfaces are important to understand chemical gradients and spatially resolved dynamic processes in various fields. Available label-free approaches are either slow or restricted to a few parameters, such as pH. We introduce here a novel chemical mapping principle for the spatially resolved sensing of optically silent ionic species at high frequency, acquiring a concentration map of millions of pixels in seconds using a conventional fluorescence microscope. The principle relies on ion transfer from a thin polymeric film into a solution phase, electrochemically coupled to electron transfer at the back side of the film. Different solution concentrations change the potential at which ion transfer is observed, which is visualized by unquenching a fluorophore when the redox probe in the film is electrochemically oxidized. The…
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Taxonomy
TopicsAnalytical Chemistry and Sensors · Electrochemical Analysis and Applications · Force Microscopy Techniques and Applications