A Novel Mitochondria‐Associated Programmed Cell Death–Related Prognostic Model and Validation of Oncogene INHBB in Colorectal Cancer
Yanqing Sun, Chun Gao, Dong Jia, Qiang Ma, Wei Wang
TL;DR
This study identifies a new prognostic model for colorectal cancer based on mitochondria-related genes and shows that the INHBB gene promotes cancer growth.
Contribution
A novel mitochondria-associated programmed cell death-related prognostic model and experimental validation of the oncogenic role of INHBB in colorectal cancer.
Findings
A prognostic model using four mtPCD-related genes (ACSL6, INHBB, GPR15, SRPX) was developed with moderate predictive accuracy.
INHBB was found to be upregulated in CRC cells and its downregulation reduced cancer cell proliferation and migration.
Significant differences in immune infiltration and drug sensitivity were observed between high- and low-risk groups.
Abstract
The objective of this study is to explore mitochondria‐associated programmed cell death (mtPCD)–related key biomarkers for patients with colorectal cancer (CRC). CRC‐related datasets were obtained from the GEO and TCGA databases, and mitochondria‐related genes (MitoRGs) and PCD‐related genes (PCDRGs) were acquired from the MitoCarta database or pertinent literature. After differentially expressed gene (DEG) screening, the DEmtPCD coexpressed genes were identified. Then, consensus clustering analysis was conducted, followed by GSEA and immune infiltration analysis. In addition, a prognostic model was constructed, and then, immune infiltration analysis, GSEA, and drug sensitivity analysis were carried out. The qRT‐PCR and western blot were employed to determine the expression of key genes. Finally, a loss‐of‐function experiment was applied to investigate the influence of INHBB on CRC in…
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Taxonomy
TopicsFerroptosis and cancer prognosis · Mitochondrial Function and Pathology · Clusterin in disease pathology