Changes in renal function parameters after cotrimoxazole therapy
John Michael Hoppe, Martin Klaus, Matthias Auer, Markus Wörnle
TL;DR
This paper reports a significant increase in creatinine and urea levels after cotrimoxazole therapy, suggesting a strong impact on kidney function.
Contribution
The study presents an unprecedented extent of renal function parameter changes caused by cotrimoxazole.
Findings
Creatinine and urea levels increased significantly after cotrimoxazole therapy.
Glomerular filtration rate decreased while cystatin-C levels remained unchanged.
The observed changes suggest a strong effect of TMP-SMX on kidney function.
Abstract
Cotrimoxazol ist ein Kombinationsantibiotikum aus den beiden Wirkstoffen Trimethoprim und Sulfamethoxazol (TMP-SMX). Es ist bekannt, dass TMP-SMX Nierenfunktionsparameter beeinflussen kann. TMP-SMX kann dabei zu tatsächlichem akutem Nierenversagen (AKI) führen, aber auch durch Hemmung der Kreatininsekretion in der Niere ein AKI vortäuschen. Der vorliegende Fall zeigt eine erhebliche, bislang in diesem Ausmaß noch nicht berichtete Erhöhung von Kreatinin- und Harnstoffwerten und eine reduzierte glomeruläre Filtrationsrate bei unveränderten Cystatin-C-Werten.
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Taxonomy
TopicsPneumocystis jirovecii pneumonia detection and treatment · Pharmacological Effects and Toxicity Studies · Antibiotics Pharmacokinetics and Efficacy