# Research progress on risk factors for in-stent restenosis following cerebrovascular stent implantation

**Authors:** Haobo Gao, Hifsa Bibi, Hongtu Tan, Yiwei Zhang, Guofang Yang, Jiabing Wang, Tao Wu

PMC · DOI: 10.3389/fneur.2025.1660202 · 2025-11-12

## TL;DR

This paper reviews the risk factors for in-stent restenosis after cerebrovascular stent implantation to guide clinical decisions.

## Contribution

The paper systematically summarizes key risk factors for in-stent restenosis following carotid artery stenting.

## Key findings

- In-stent restenosis is influenced by stent type, drug use, and patient-specific factors.
- Vascular anatomy and surgical procedures also contribute to in-stent restenosis.
- The review aims to improve clinical decision-making in neurointerventional practice.

## Abstract

Transient ischemic attack or ischemic stroke within 6 months is frequently associated with severe carotid stenosis. Carotid stent implantation is a widely employed treatment, but in-stent restenosis (ISR) is a dangerous postoperative complication. Many factors cause in-stent restenosis. Previous studies have indicated that stent type, drug use, patient-specific risk factors, levels of various factors in the patient’s body, surgical procedures, and vascular physiological anatomy can all contribute to its occurrence. This review summarizes the key risk factors for ISR following CAS and briefly discusses related findings in intracranial artery stenting, aiming to inform clinical decision-making in neurointerventional practice.

## Linked entities

- **Diseases:** ischemic stroke (MONDO:1060198), transient ischemic attack (MONDO:0005264)

## Full-text entities

- **Diseases:** CAS (MESH:D001072), ischemic stroke (MESH:D002544), carotid stenosis (MESH:D016893), ISR (MESH:D023903), ischemic attack (MESH:D002546)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12647095