Effectiveness and safety of tenofovir alafenamide in chronic hepatitis B patients over 30 years old with positive hepatitis B virus DNA: a double-center retrospective study

TL;DR

This study shows that Tenofovir Alafenamide (TAF) is effective and safe for treating chronic hepatitis B in patients over 30 years old.

Contribution

The study provides evidence that TAF is effective in younger patients and those with normal liver function.

Findings

TAF treatment significantly reduced ALT, AST, and HBV DNA levels over 48 and 96 weeks.

TAF remained effective in patients aged 30–35 and those with normal ALT levels.

TAF had minimal impact on renal function in patients with stage 2 or below chronic kidney disease.

Abstract

The aim of this study was to evaluate the effectiveness and safety of Tenofovir Alafenamide (TAF) in chronic hepatitis B (CHB) patients, particularly those aged 30–35 years or with baseline normal alanine aminotransferase (ALT) levels.

A total of 191 patients were recruited, and their data were collected from two hospital in China from January 2017 to March 2023. Liver function and HBV-related indicators were measured at baseline, 48-week, and 96-week. The safety and effectiveness of TAF were evaluated in the high-age group (> 35 years) and the low-age group (30–35 years), as well as in the ALT-normal group (ALT < 1 × ULN) and the ALT-elevated (ALT ≥ 1 × ULN) group.

TAF treatment for 48 weeks or 96 weeks could significantly improve the progression of hepatitis as evidenced by lower ALT, AST, and HBV DNA. TAF is still effective for patients aged 30–35 or those with normal ALT levels. Additionally, for CHB patients with baseline chronic kidney disease staging at stage 2 or below, 1–2 years of TAF treatment has minimal impact on their renal function.

TAF treatment significantly alleviated the progression of CHB patients over a 96-week follow-up period. TAF remains effective for younger patients or those with normal liver function, providing evidence for further expanding antiviral indications.

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