# One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation **Authors:** Epaminondas Doxakis, Yuan Chao Xue, Anca F. Savulescu PMC · DOI: 10.3389/fnmol.2025.1716825 · 2025-11-12 ## Full-text entities - **Genes:** CCR4 (C-C motif chemokine receptor 4) [NCBI Gene 1233] {aka CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099}, DCP1B (decapping mRNA 1B) [NCBI Gene 196513] {aka DCP1}, ALYREF (Aly/REF export factor) [NCBI Gene 10189] {aka ALY, ALY/REF, BEF, REF, THOC4}, ATF4 (activating transcription factor 4) [NCBI Gene 468] {aka CREB-2, CREB2, TAXREB67, TXREB}, XPO1 (exportin 1) [NCBI Gene 7514] {aka CRM-1, CRM1, emb, exp1}, RPL22 (ribosomal protein L22) [NCBI Gene 6146] {aka EAP, HBP15, HBP15/L22, L22, eL22}, IMPA1 (inositol monophosphatase 1) [NCBI Gene 3612] {aka IMP, IMPA, MRT59}, PUM1 (pumilio RNA binding family member 1) [NCBI Gene 9698] {aka HSPUM, NEDMSF, PUMH, PUMH1, PUML1, SCA47}, Cpsf5 (Cleavage and polyadenylation specific factor 5) [NCBI Gene 39083] {aka CDI12, CF I[[m]]25, CFI25, CFIm25, CG3689, Cdi12}, PAN3 (poly(A) specific ribonuclease subunit PAN3) [NCBI Gene 255967], IGKV3-7 (immunoglobulin kappa variable 3-7 (non-functional)) [NCBI Gene 28915] {aka IGKV37, L10, L10a, Vh}, CLIP2 (CAP-Gly domain containing linker protein 2) [NCBI Gene 7461] {aka CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3}, TARDBP (TAR DNA binding protein) [NCBI Gene 23435] {aka ALS10, TDP-43}, IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2) [NCBI Gene 10644] {aka IMP-2, IMP2, VICKZ2}, GAPDH (glyceraldehyde-3-phosphate dehydrogenase) [NCBI Gene 2597] {aka G3PD, GAPD, HEL-S-162eP}, EIF2A (eukaryotic translation initiation factor 2A) [NCBI Gene 83939] {aka CDA02, EIF-2A, MST089, MSTP004, MSTP089}, PAN2 (poly(A) specific ribonuclease subunit PAN2) [NCBI Gene 9924] {aka DEDCRF, USP52}, ZBP1 (Z-DNA binding protein 1) [NCBI Gene 81030] {aka C20orf183, DAI, DLM-1, DLM1}, elav (embryonic lethal abnormal vision) [NCBI Gene 31000] {aka 44C11, 9F8A9, CG4262, Dmel\CG4262, EC7, EG:65F1.2}, ANP32B (acidic nuclear phosphoprotein 32 family member B) [NCBI Gene 10541] {aka APRIL, PHAPI2, SSP29}, IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1) [NCBI Gene 10642] {aka CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1}, NXF1 (nuclear RNA export factor 1) [NCBI Gene 10482] {aka MEX67, TAP}, SYNJ2BP (synaptojanin 2 binding protein) [NCBI Gene 55333] {aka ARIP2, OMP25}, HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1) [NCBI Gene 3181] {aka HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2}, PRKN (parkin RBR E3 ubiquitin protein ligase) [NCBI Gene 5071] {aka AR-JP, LPRS2, PARK2, PDJ}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}, MAP1B (microtubule associated protein 1B) [NCBI Gene 4131] {aka DFNA83, FUTSCH, MAP5, PPP1R102, PVNH9}, FMR1 (fragile X messenger ribonucleoprotein 1) [NCBI Gene 2332] {aka FMRP, FRAXA, POF, POF1}, DCP2 (decapping mRNA 2) [NCBI Gene 167227] {aka NUDT20}, PINK1 (PTEN induced kinase 1) [NCBI Gene 65018] {aka BRPK, PARK6}, SYNJ2 (synaptojanin 2) [NCBI Gene 8871] {aka INPP5H}, HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) [NCBI Gene 3178] {aka ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, MPD3}, LARP1 (La ribonucleoprotein 1, translational regulator) [NCBI Gene 23367] {aka LARP, Lar1, Lhp1}, APC (APC regulator of Wnt signaling pathway) [NCBI Gene 324] {aka BTPS2, DESMD, DP2, DP2.5, DP3, GS}, TIA1 (TIA1 cytotoxic granule associated RNA binding protein) [NCBI Gene 7072] {aka ALS26, TIA-1, WDM}, NOP2 (NOP2 nucleolar protein) [NCBI Gene 4839] {aka NOL1, NOP120, NSUN1, p120}, TRUB1 (TruB pseudouridine synthase family member 1) [NCBI Gene 142940] {aka PUS4}, RNU6-1 (RNA, U6 small nuclear 1) [NCBI Gene 26827] {aka RNU6, RNU6A, RP103, U6, U6-1}, MALAT1 (metastasis associated lung adenocarcinoma transcript 1) [NCBI Gene 378938] {aka HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, miPEP-52}, SNCA (synuclein alpha) [NCBI Gene 6622] {aka NACP, PARK1, PARK4, PD1}, BDNF (brain derived neurotrophic factor) [NCBI Gene 627] {aka ANON2, BULN2}, PABPC1 (poly(A) binding protein cytoplasmic 1) [NCBI Gene 26986] {aka PAB1, PABP, PABP1, PABPC2, PABPL1}, PQBP1 (Poly-glutamine tract binding protein 1) [NCBI Gene 43004] {aka CG11820, Dmel\CG11820, PQBP-1, dPQBP-1, dPQBP1, dpqbp1}, YTHDF1 (YTH N6-methyladenosine RNA binding protein F1) [NCBI Gene 54915] {aka C20orf21, DF1}, POTEF (POTE ankyrin domain family member F) [NCBI Gene 728378] {aka A26C1B, POTE2alpha, POTEACTIN}, NSUN2 (NOP2/Sun RNA methyltransferase 2) [NCBI Gene 54888] {aka MISU, MRT5, SAKI, TRM4}, HNRNPD (heterogeneous nuclear ribonucleoprotein D) [NCBI Gene 3184] {aka AUF1, AUF1A, HNRPD, P37, hnRNPD0}, HMGA2 (high mobility group AT-hook 2) [NCBI Gene 8091] {aka BABL, HMGI-C, HMGIC, LIPO, SRS5, STQTL9}, RN7SK (RNA component of 7SK nuclear ribonucleoprotein) [NCBI Gene 125050] {aka 7SK}, FUS (FUS RNA binding protein) [NCBI Gene 2521] {aka ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS}, TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1) [NCBI Gene 7073] {aka TCBP, TIAR}, COX7C (cytochrome c oxidase subunit 7C) [NCBI Gene 1350], TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, ANP32A (acidic nuclear phosphoprotein 32 family member A) [NCBI Gene 8125] {aka C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1}, RBFOX1 (RNA binding fox-1 homolog 1) [NCBI Gene 54715] {aka 2BP1, A2BP1, FOX-1, FOX1, HRNBP1}, XRN1 (5'-3' exoribonuclease 1) [NCBI Gene 54464] {aka SEP1} - **Diseases:** toxicity (MESH:D064420), cortical hyperexcitability (MESH:D054220), learning deficits (MESH:D007859) - **Chemicals:** actinomycin D (MESH:D003609), 5'-TOP (-), thiol (MESH:D013438), sodium arsenite (MESH:C017947), sucrose (MESH:D013395), poly(A) (MESH:D011061), cycloheximide (MESH:D003513), thapsigargin (MESH:D019284), leptomycin B (MESH:C038753), 5-bromouridine (MESH:C006824) - **Species:** Homo sapiens (human, species) [taxon 9606], Drosophila melanogaster (fruit fly, species) [taxon 7227], Mus musculus (house mouse, species) [taxon 10090] - **Cell lines:** SNCA — Homo sapiens (Human), Parkinson disease 1, autosomal dominant, Induced pluripotent stem cell (CVCL_YR02) ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12647009/full.md --- Source: https://tomesphere.com/paper/PMC12647009