Psychological states mediate the relationship between sleep quality and frailty among older adults

TL;DR

Poor sleep quality increases frailty in older adults mainly through anxiety and depression, and these effects can be reduced by managing pain and eating well.

Contribution

This study identifies anxiety and depression as key mediators linking poor sleep to frailty and reveals modifiable lifestyle factors that can weaken this pathway.

Findings

Anxiety and depression partially mediate the relationship between poor sleep quality and frailty in older adults.

Bodily pain, dietary habits, and outdoor exercise moderate the sleep quality-anxiety link.

Modifiable factors like diet and exercise can reduce the impact of poor sleep on frailty via anxiety.

Abstract

Frailty prevalence is high among older adults. While the association between poor sleep quality and frailty is established, the mediating role of psychological states (anxiety/depression) and the moderating influence of multidimensional factors (physiological conditions, dietary habits, and lifestyle factors) on this pathway remain unclear. This study aimed to examine the mediating effects of anxiety and depression on the sleep quality-frailty link and identify moderators of the sleep quality-psychological state relationship among community-dwelling older adults.

A cross-sectional survey was conducted among 900 adults aged ≥60 years in Dongge Community, Nanning, Guangxi. Sleep quality, anxiety, depression, and frailty were assessed using the Pittsburgh sleep quality index (PSQI), hospital anxiety and depression scale (HADS-A/HADS-D), and FRAIL scale, respectively. Data on physiological conditions, dietary habits, and lifestyle factors were collected via questionnaire. Parallel mediation and moderated mediation analyses were performed.

Mean scores were: HADS-A = 1.00 ± 1.76, HADS-D = 1.32 ± 2.11, PSQI = 6.41 ± 3.22, and FRAIL = 0.96 ± 1.05. Parallel mediation analyses confirmed that both anxiety (B = 0.029, 95%CI [0.004, 0.060]) and depression (B = 0.018, 95%CI [0.001, 0.042]) partially mediated the association between poor sleep quality and frailty, collectively accounting for 23.50% of the total effect. Moderated mediation analyses revealed that bodily pain, specific dietary habits (intake frequency ≥5 times/week of milk, soybeans, and fish/meat/eggs), and daily outdoor exercise duration (≥30 min) significantly moderated the strength of the mediating pathway through anxiety (i.e., the “sleep quality → anxiety” link).

Anxiety and depression significantly mediate the relationship between poor sleep quality and frailty in older adults. Crucially, this mediating pathway via anxiety is modifiable, being attenuated by the absence of bodily pain, frequent consumption of key protein-rich foods, and regular outdoor exercise. These findings highlight potential targets for multi-faceted interventions aimed at mitigating frailty risk by improving sleep and psychological well-being in aging populations.

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