# Allergen characterization in childhood asthma: a retrospective cohort study in China

## TL;DR

This study identifies common allergens in Chinese children with asthma, showing how allergen patterns vary with age and could help improve personalized treatment.

## Contribution

The study provides a detailed characterization of allergen sensitization patterns in Chinese children with asthma, highlighting age-related differences.

## Key findings

- House dust mites had the highest sensitization rate among inhaled allergens in Chinese children with asthma.
- Food allergens like egg white and milk showed higher sensitization rates in younger children (0–3 years) compared to older children.
- Multi-allergen sensitization, especially involving house dust mites, was the most common profile observed.

## Abstract

The increasing cases of asthma in children around the world necessitate the profiling of regional specific allergens to manage it precisely. This research study identifies the sensitization patterns of Chinese children with asthma and the necessity of its undertaking for the prevention of this chronic respiratory illness that is prevalent in children.

We selected and included 6,785 pediatric patients with a clinical diagnosis of bronchial asthma at the Children’s Hospital Affiliated to Shandong University from January 2018 to January 2025 with the cohort study design. Serum specific IgE (sIgE) was tested in all patients for 19 types of inhalant and food allergens.

In this study, house dust mites (HDMs) (52.99%) had the highest positive rate of, followed by molds (31.98%) and dog dander (28.17%). Food allergens that had the highest positive rates were egg white (32.45%), milk (19.96%) and beef (16.32%). The positive rate of the food allergens was higher in the 0–1 year-old group and the 1–3 year-old group compared to the inhaled allergens. On the other hand, inhaled allergens were more frequently positive than food allergens among children aged 3 to 6 years, 6 to 12 years, and over 12 years, with some of the differences being statistically significant. The positive rates of inhaled allergens were higher than those of food allergens in all months in terms of monthly distribution. Multi-allergen sensitization, in particular, the linking of HDMs with other allergens, was the most common sensitization profile identified in this study.

The results of this study will be of great use in the transformation of experience-based diagnosis and treatment of childhood asthma into a standardized and personalized model on the basis of precise distribution of allergen. The change will reduce the occurrence of asthma attacks, enhance the quality of life of children and have much practical and clinical significance associated with the enhancement of the prevention and treatment of childhood asthma in the region.