# Syncope in a Patient With an Extensive Thoracolumbosacral Myxopapillary Ependymoma

**Authors:** Alice S Wang, Nicole A Nguyen, Louis Reier, Jessica Dally, Carolyn S Leach, Ahmad Ibrahim, Dan E Miulli

PMC · DOI: 10.7759/cureus.95457 · 2025-10-26

## TL;DR

A young woman with syncope was found to have a rare spinal tumor, showing that unusual symptoms can indicate spinal issues.

## Contribution

This case report presents syncope as an atypical presentation of thoracolumbosacral myxopapillary ependymoma.

## Key findings

- A T10-S2 myxopapillary ependymoma was identified in a patient with syncope and neurological symptoms.
- Subtotal debulking of the tumor led to resolution of the patient's symptoms postoperatively.

## Abstract

Myxopapillary ependymomas are most commonly found involving the conus medullaris, cauda equina, and filum terminale, causing lower extremity symptoms, whereas atypical presentations such as syncope are rare. A 20-year-old woman presented with multiple syncopal episodes, headache, visual changes, and lower extremity paresis. Imaging revealed a T10-S2 myxopapillary ependymoma and mild ventriculomegaly. The patient underwent subtotal debulking, and histopathologic examination confirmed a WHO Grade II myxopapillary ependymoma. Postoperatively, her symptoms resolved. This case highlights the importance of evaluating spinal pathology in patients with atypical presentations of syncope.

## Linked entities

- **Diseases:** myxopapillary ependymoma (MONDO:0016699)

## Full-text entities

- **Diseases:** ventriculomegaly (MESH:D006849), Myxopapillary Ependymoma (MESH:D004806), paresis (MESH:D010291), Syncope (MESH:D013575), headache (MESH:D006261)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12646564/full.md

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Source: https://tomesphere.com/paper/PMC12646564