The impact of nutritional support therapy combined with conventional treatment models on short-term symptom improvement and complications in stroke patients: a systematic review and meta-analysis

TL;DR

Combining nutritional support with standard treatment for stroke patients may improve recovery and reduce infections, but the evidence is limited due to study inconsistencies.

Contribution

This study provides a systematic review and meta-analysis on the combined use of nutritional support and conventional treatment for stroke patients.

Findings

Nutritional support improved GCS scores, nutritional markers, and immune parameters in stroke patients.

Pro-inflammatory cytokines were reduced, and infection rates were lower in the intervention group.

High heterogeneity among studies suggests caution in interpreting the results.

Abstract

To methodically assess the effectiveness of nutritional support therapy combined with conventional treatment on short-term symptom improvement, nutritional and immune recovery, and complication rates in stroke patients.

A thorough literature search was carried out utilizing PubMed, EMBASE, ScienceDirect, the Cochrane Library, and major Chinese databases (CNKI, VIP, Wanfang, and CBM) from inception to the present. Randomized controlled trials (RCTs) evaluating the impact of nutritional support in stroke patients were included. Two reviewers independently extracted the data, and the Cochrane Handbook 5.3 was used to determine the risk of bias. RevMan 5.3 was used to conduct the meta-analysis.

Following PRISMA guidelines, 1,693 records were retrieved and screened, resulting in the inclusion of 8 randomized controlled trials with a total of 727 individuals. Meta-analysis revealed that nutritional support significantly improved Glasgow Coma Scale (GCS) scores, serum markers of nutritional status (Hb, TLC), and immune parameters (IgA, IgG, IgM). Pro-inflammatory cytokines (IL-2, IL-6, TNF-α) were significantly reduced. Moreover, the incidence of infectious complications was lower in the intervention group. However, heterogeneity among studies was high in several analyses, warranting cautious interpretation.

Nutritional support combined with conventional therapy improves nutritional and immune recovery and reduces infection risk in stroke patients. However, given the high heterogeneity and methodological limitations of included trials, the certainty of evidence remains low to very low, and these results should be interpreted cautiously.

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