# The clinical impact of herpesvirus testing on multiplex PCR panels in a pediatric population

**Authors:** Caitlin Naureckas Li, Cecilia Thompson, Brittany Hunter, Elizabeth Dobler, Natalie Jachym, Emaan Mohsin, Marcelo Malakooti, Lisa Akhtar

PMC · DOI: 10.1017/ash.2025.10242 · Antimicrobial Stewardship & Healthcare Epidemiology : ASHE · 2025-11-25

## TL;DR

This study examines how testing for herpesviruses in a pediatric PCR panel for meningitis/encephalitis affects clinical outcomes.

## Contribution

The study provides insights into the clinical utility of including herpesvirus targets in a meningitis/encephalitis PCR panel for children.

## Key findings

- Herpesvirus detection led to changes in clinical management in a subset of pediatric patients.
- The inclusion of herpesvirus targets in the PCR panel had diagnostic and therapeutic implications.

## Abstract

The use of multiplex polymerase chain reaction (PCR) panels for diagnosis of clinical syndromes is rapidly growing despite limited data on optimal use cases. We retrospectively reviewed the clinical impact and consequences of the inclusion of herpesvirus targets on the meningitis/encephalitis PCR panel.

## Linked entities

- **Diseases:** meningitis (MONDO:0021108), encephalitis (MONDO:0019956)

## Full-text entities

- **Diseases:** encephalitis (MESH:D004660), meningitis (MESH:D008580)
- **Species:** herpesvirus [taxon 39059]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12645241/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12645241/full.md

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Source: https://tomesphere.com/paper/PMC12645241