# Potential Mechanisms of COVID-19 Related Nervous System Damage and Effects on Female Fertility

**Authors:** Chen-yue Qian, Si-ning Hu, Hua-dong Liu, Jing-jin Liu

PMC · DOI: 10.2174/0109298673333968241011092801 · Current Medicinal Chemistry · 2024-10-24

## TL;DR

The paper explores how long-COVID may affect the nervous system and female fertility, and suggests possible treatment approaches.

## Contribution

The paper reviews potential mechanisms linking long-COVID to nervous system damage and fertility issues in women.

## Key findings

- Long-COVID symptoms may be caused by abnormal autonomic nervous system activity and autoimmune reactions.
- Impaired female fertility may be linked to inflammation and immune responses triggered by COVID-19.
- Few treatment options are currently available for long-COVID symptoms.

## Abstract

Signs and symptoms that persist or worsen beyond the “acute COVID-19” stage are referred to as long-COVID. These patients are more likely to suffer from multiple organ failure, readmission, and mortality. According to a recent theory, long-lasting COVID-19 symptoms may be caused by abnormal autonomic nervous system (ANS) activity, such as hypovolemia, brain stem involvement, and autoimmune reactions. Furthermore, COVID-19 can also cause impaired fertility in women, which may also be related to inflammation and immune responses. Currently, few treatments are available for long-COVID symptoms. This article reviews the major effects of COVID-19 on the nervous system and female fertility, as well as offers potential treatment approaches.

## Full-text entities

- **Diseases:** COVID-19 (MESH:D000086382), Nervous System Damage (MESH:D020196), long-COVID (MESH:D000094024), impaired fertility (MESH:D007246), inflammation (MESH:D007249), autoimmune reactions (MESH:D001327), multiple organ failure (MESH:D009102), hypovolemia (MESH:D020896)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12645119/full.md

## References

135 references — full list in the complete paper: https://tomesphere.com/paper/PMC12645119/full.md

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Source: https://tomesphere.com/paper/PMC12645119