# Recombinant Platelet-Derived Growth Factor-BB (rhPDGF-BB) Augmented Collagen Grafting for Oral Mucosal Defect Reconstruction

## TL;DR

This study compares collagen grafting with and without rhPDGF-BB for oral mucosal defect reconstruction, finding potential benefits with the addition of rhPDGF-BB.

## Contribution

The study evaluates the clinical benefits of adding rhPDGF-BB to collagen grafts for oral mucosal reconstruction.

## Key findings

- Collagen grafting showed good haemostasis, pain relief, granulation, and epithelialisation.
- rhPDGF-BB augmented grafts showed slightly better outcomes but results were not statistically significant.
- Further research with larger samples is needed to confirm the benefits of rhPDGF-BB.

## Abstract

To assess the suitability of collagen grafting and compare the outcomes between rhPDGF-BB (recombinant human platelet-derived growth factor-BB) augmented collagen grafting and collagen alone grafting for oral mucosal defect reconstruction.

A total of 30 patients, who were planned for surgical excision of various intraoral lesions, participated in the study. These participants were then randomly assigned into two groups. Group I underwent reconstruction with collagen sheet with rhPDGF-BB, while group II underwent reconstruction with collagen sheet alone. Post-operatively, haemostasis, pain, granulation, epithelialisation and healing contracture were assessed.

The lesions that were treated included leucoplakia, erythroplakia, oral submucous fibrosis and verrucous carcinoma. Use of collagen was associated with good haemostasis, pain relief, granulation tissue formation and epithelialisation. Group I was found to develop slightly better granulation tissue, epithelisation and lesser degree of tissue contracture compared to group II, although these results were not significant statistically (p value = 0.464, 0.705 and 1.000 respectively).

This study shows that use of collagen graft augmented with rhPDGF-BB could be beneficial in oral cavity reconstruction following resection of small lesions, although further research with larger sample size is proposed to confirm the benefit.