# The Clear Cell Odontogenic Carcinoma: Case Report of a Rare Jaw Malignancy

**Authors:** Vasco Starke, Markus Merkl, Lukas Grössing, Mauro Pau, Wolfgang Zemann

PMC · DOI: 10.1007/s12663-025-02590-5 · Journal of Maxillofacial & Oral Surgery · 2025-07-11

## TL;DR

This paper reports a rare case of clear cell odontogenic carcinoma in a young man, highlighting its aggressive nature and successful treatment through surgery and follow-up.

## Contribution

The paper presents a detailed case report of a rare jaw malignancy with long-term follow-up and successful treatment outcomes.

## Key findings

- Clear cell odontogenic carcinoma was successfully treated with surgical resection and lymph node removal.
- The patient showed no tumor recurrence after 7.5 years of follow-up.
- Diagnosis required immunohistopathology due to variable clinical presentation.

## Abstract

Clear cell odontogenic carcinoma is a very rare malignant tumor of the jaw. Diagnosis and treatment may be challenging as the tumor grows locally aggressive and infiltrative with possible metastatic spread, while the clinical presentation varies, and the definitive diagnosis can only be confirmed by immunohistopathology. The case of a 25-year-old male patient with clear cell odontogenic carcinoma of the mandible is presented. Therapeutic treatment included primary surgical resection with bilateral removal of cervical lymph nodes followed by a two-stage reconstruction approach. Continuous follow-up over 7.5 years showed no signs of tumor recurrence.

## Full-text entities

- **Diseases:** tumor (MESH:D009369), Jaw Malignancy (MESH:D007573), Clear Cell Odontogenic Carcinoma (MESH:D002292)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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Source: https://tomesphere.com/paper/PMC12644347