# Impact of low-level laser therapy on orthodontic pain

**Authors:** Sylwia Jagła, Hanna Bielawska-Victorini, Krzysztof Woźniak

PMC · DOI: 10.3389/fneur.2025.1666348 · Frontiers in Neurology · 2025-11-11

## TL;DR

Low-level laser therapy (LLLT) reduces orthodontic pain and improves oral hygiene without side effects, offering a non-drug alternative for patients.

## Contribution

This study provides empirical evidence that LLLT is an effective and safe non-pharmacological intervention for acute orthodontic pain.

## Key findings

- LLLT significantly reduced pain perception compared to the control group, with a highly significant difference by day 4.
- The LLLT group showed significantly better oral hygiene with lower plaque index scores.
- LLLT is a safe, localized treatment with no systemic side effects.

## Abstract

Pain is a primary deterrent to patient compliance in orthodontics. While pharmacological options exist, their systemic side effects warrant exploration of non-invasive alternatives. This study introduces Low-Level Laser Therapy (LLLT) as a localized, non-pharmacological intervention and evaluates its efficacy in mitigating pain during the critical initial phase of fixed appliance treatment.

In this prospective controlled study, 60 patients (aged 14.6–37.1 years) were randomized into an LLLT group (n = 20) and a control group (n = 40). The LLLT group received daily photobiomodulation (670 nm, 4–6 J/cm2) for five consecutive days post-appliance placement. Pain was assessed daily using the Visual Analogue Scale (VAS), Laitinen Scale, and Verbal Rating Scale (VRS). Oral hygiene was evaluated using the Approximal Plaque Index (API).

LLLT significantly reduced pain perception. Pain peaked on day 2 for both groups, but the VAS score was lower in the LLLT group (4.35) than the control group (5.30). By day 4, the difference was highly significant (LLLT: 2.05 vs. Control:3.77; p < 0.0014). Furthermore, the LLLT group demonstrated significantly better oral hygiene, with a lower increase in API scores from T0 to T5 compared to the control group (p < 0.0003).

LLLT is an effective and safe modality for reducing acute orthodontic pain. Its localized action, absence of systemic side effects, and positive influence on oral hygiene make it available clinical tool for improving patient comfort and compliance during orthodontic therapy. This study provides strong evidence supporting the integration of LLLT into routine orthodontic practice.

## Full-text entities

- **Diseases:** Pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

10 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12644082/full.md

## References

47 references — full list in the complete paper: https://tomesphere.com/paper/PMC12644082/full.md

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Source: https://tomesphere.com/paper/PMC12644082